Longevity & metabolic

This review explores circulating biomarkers of senescence in humans and their implications for age-related health issues, alongside potential therapeutic interventions.

This study explores how blood cell composition affects DNA methylation age and its implications for health outcomes, revealing distinct biological interpretations.

This study explores how blood cell composition affects DNA methylation age and age acceleration, revealing distinct biological interpretations and modest implications for health outcomes.

This study benchmarks proteomic organ clocks against established ageing biomarkers and identifies proteins associated with all-cause mortality in a cohort of older adults.

A study investigates the effects of supraphysiological ascorbic acid infusion on cerebrovascular function in middle-aged and older adults, suggesting potential benefits in vascular health.

This randomized crossover study investigates how manipulating sleep duration affects serum brain-derived neurotrophic factor (BDNF) levels in adolescents at risk for type 2 diabetes.

This randomized crossover study investigates how manipulating sleep duration affects serum brain-derived neurotrophic factor (BDNF) levels in adolescents with severe obesity at risk for type 2 diabetes.

This review discusses cellular senescence’s role in skin aging and the potential of senolytic and senomorphic therapies to improve dermatological health.

This review discusses the role of cellular senescence in skin aging and the potential of senolytic and senomorphic therapies to address dermatological issues.

This review consolidates evidence on circulating biomarkers of senescence in humans, exploring their impact on health and potential therapeutic interventions.